Dear friends,
Hello again & Happy Tuesday!
I hope you are having a good start to the week.
It is great to see you again back @ the healthiest spot of your inbox, taking a proactive step towards investing in yourself.
Let's dive right in...
[In this episode]
What do you think happens to your brain if you are under consuming calories, either intentionally, or unintentionally?
Remember our brain cells have extremely high energy requirements and the brain can consume 25-30% of our energy needs.
We know that the brain experiences negative consequences facing low ATP including for example:
- Mitochondrial dysregulation which can promote generation of reactive oxygen species (ROS)
- ROS contributes to DNA damage in the neurons by way of increased oxidation
- Elevated DNA damage promotes mutagenesis which further contributes to compromised cognitive performance & neurodegeneration
Some sources of genomic instability in the brain cells include:
(A) Mitochondrial dysfunction
(B) Transcription - elevated transcription or defective repair machinery
(C) Protein aggregation
(D) Impaired Proteostasis
At the end of the day, remember this:
Defective DNA repair causes DNA damage in various brain cell times to build up, further trigger neuroinflammation.
At the low end of the spectrum affecting cognitive performance (manifesting in low grade symptoms such as chronic fatigue, brain fog, inability to focus, etc.).
At the further end of the spectrum potentially contributing to neurodegeneration including MS, Parkinsons, Huntingtons, AD, ALS, and the like.
Can low energy states in an otherwise healthy person (otherwise functional mitochondria) affect the brain’s own DNA repair mechanism?
Not sure, but better be safe...
Neuroinflammation triggered by DNA Damage (DNA damage can happen in glia or in neurons) 👇🏻
.... and don't be afraid to nourish yourself with excellent nutrition.
[Logistics]
Here's an updated list of all Series currently running in the Vault:
- Geroprotective Compounds & Agents
- Cognitive Prowess / Nootropics
- Longevity Formula: Blue Zones
- Microbiome / Gut Microbiome
- Organ health & longevity
- Phytonutrients
- Nutritional Excellence
- Fatty acids
- Stress /Alertness/Wakefulness
- Cellular Health & Hallmarks of aging
- DNA Methylation & Epigenetics
- Proteins, muscle and aging pathways
- My 8 Supplement stacks
- Circadian rhythm
- Thyroid health
- Hair health
If you are new and have missed any of the released series drop me a line and I'll send it to you.
